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@njconfused I used to travel for work a lot, pre-covid. I found the best remedy was red wine, and lots of it. Tank as much as possible in the lounge beforehand. Have as much as they'll let you on the plane. If decent business class, have the port with the cheeseboard dessert as well. Try...

@lucakes If that were true, we'd get it more when travelling in the same timezone (e.g. North->South) but this doesn't tend to happen. I'm sure the factors you mention are relevant (plus travelling is tiring generally), but I'd argue sleep/wake cycle disruption is the larger part.